The goal of the Tone Laboratory, focused on tumor and molecular immunology, is to develop new cancer therapeutic strategies by controlling the immune responses. Some cancer cells are able to survive by evading the immune responses through the immunosuppressive activity of regulatory T (Treg) cells. We are therefore trying to control T cell-mediated immune responses to activate antitumor immunity. To understand regulation of the immune responses, we are investigating transcriptional and posttranscriptional regulation in T cells and antigen-presenting cells (APCs).
The Tone Laboratory is affiliated with the Department of Biomedical Sciences.
- Regulation of Foxp3-mediated transcription
- Roles of Gitr and Ox40 in regulating Teff and Treg cell activities
- Controlling alternative splicing for cancer therapy
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Tone Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Liu NA, Araki T, Cuevas-Ramos D, Hong J, Ben-Shlomo A, Tone Y, Tone M, Melmed S.
J Clin Endocrinol Metab. 2015;100(7):2557-2564.
Tone Y, Kidani Y, Ogawa C, Yamamoto K, Tsuda M, Peter C, Waldmann H, Tone M.
J Immunol. 2014;192(8):3915-3924.
Sin J, Andres AM, Taylor DJ, Weston T, Hiraumi Y, Stotland A, Kim BJ, Huang C, Doran KS, Gottlieb RA.
Contact the Tone Lab
8700 Beverly Blvd.
Davis Building, Room 5005
Los Angeles, CA 90048