Novel therapeutic platforms, which are based on biological therapies, are required to overcome extensive skeletal tissue loss or degeneration and to replace the currently used synthetic prostheses. Complex clinical challenges, such as intervertebral disc degeneration, multiple rib fractures, tendon and ligament injuries, non-union fractures, osteoarthritis and diagnosing lower-back pain pose a great challenge both to health systems and to clinicians. The Gazit Laboratory has been investigating the use of adult mesenchymal stem cells (MSCs) for skeletal tissue regeneration for the last 20 years and recently developed promising studies based on induced pluripotent stem cells (iPSC) and also gene therapy for bone and intervertebral disc (IVD) regeneration. The Gazit Lab is exploring a promising approach that involves the use of MRI to detect small chemical changes in IVDs. This method is accurate, non-invasive and allows for a much more targeted course of action to mitigate lower-back pain. We succeed in implementing the use of ultrasound-mediated gene delivery to enable accelerated bone and ligament/tendon repair after critical fractures and ruptures that don't spontaneously heal. The Gazit Laboratory is developing a unique approach that combines the use of bone allografts, produced in tissue banks, and a recombinant hormone to restore the original structure of the damaged jaw after massive bone loss. Moreover, having already successfully implanted bio-scaffolds in arthritic wrist joints, we are challenged now with expanding the usability of this technique to the weight-bearing knee joint.
In summary, studies in the Gazit Lab have shown that stem cells and gene therapy were able to regenerate tissues in a wide variety of skeletal injury models including complex limb, skull, rib and jaw fractures and even tendon tears.
The Gazit Laboratory is affiliated with the Cedars-Sinai Regenerative Medicine Institute, Biomedical Imaging Research Institute, Surgery Department and Orthopaedics Department.
The Gazit Lab has a unique structure of partnership in research running together for almost 20 years. The team of Dan Gazit, DMD, PhD, Zulma Gazit, PhD, and Gadi Pelled, PhD, began at the Hebrew University of Jerusalem, Israel, and moved to Cedars-Sinai to initiate the Skeletal Program in the Regenerative Medicine Institute. The synergistic activity of the scientists in the Gazit Lab makes possible to advance a diversity of projects including stem cell and gene therapies as well as imaging modalities.
- Targeting of Endogenous Stem Cells for Segmental Bone Fracture Repair
- Noninvasive Method for Diagnosing Low Back Pain
- Knee Cartilage Resurfacing Utilizing Bio-Scaffolds
- Reconstruction of Massive Bone Loss in the Jaws Utilizing Bone Allografts and a Recombinant Hormone
- Human Induced Pluripotent Stem Cells (iPSC) Can Be Differentiated into Notochordal Cells that Reduce Intervertebral Disc Degeneration in a Porcine Model
- Hani A. Awad, PhD, University of Rochester Medical Center
- Katherine Ferrara, PhD, Stanford University
- Thomas J. Kremen, MD, University of California Los Angeles
- Edward M. Schwarz, PhD, University of Rochester Medical Center
Meet Our Team
Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Gazit Laboratory, whose dedicated efforts lead to groundbreaking discoveries.
Sheyn D, Ben-David S, Tawackoli W, Zhou Z, Salehi K, Bez M, De Mel S, Chan V, Roth J, Avalos P, Giaconi JC, Yameen H, Hazanov L, Seliktar D, Li D, Gazit D, Gazit Z.
Theranostics. 2019 Oct 12;9(25):7506-7524.
Bez M, Zhou Z, Sheyn D, Tawackoli W, Giaconi JC, Shapiro G, Ben David S, Gazit Z, Pelled G, Li D, Gazit D.
Sci Rep. 2018 Nov;8(1):17363.
Séguin CA, Chan D, Dahia CL, Gazit Z.
JOR Spine. 2018 Sep;1(3):e1030.
Bez M, Kremen TJ, Tawackoli W, Avalos P, Sheyn D, Shapiro G, Giaconi JC, Ben David S, Snedecker JG, Gazit Z, Ferrara KW, Gazit D, Pelled G.
Mol Ther. 2018 Jul 5;26(7):1746–1755.
Contact the Gazit Lab
8700 Beverly Blvd.
Advanced Health and Sciences Pavilion, Room 8304
Los Angeles, CA 90048